Experimental Models on Diabetes: A Comprehensive Review
نویسندگان
چکیده
Present world scenario globally, upto 2010, around 285 million people suffering from Type 2 diabetes making up about 90% of the cases. According to statistics, by 2030, this number is estimated to almost double. Diabetes mellitus occurs throughout the world, but is more common (especially Type 2) in the more developed countries. The greatest increase in prevalence is, however, expected to occur in Asia and Africa, where most patients will probably be found by 2030. The aim of this review is to summarize several studies done for the discovery of new drug using different animal models for in vivo studies (chemical, surgical, and genetic models ) & in vitro models (glucose uptake, pancreatic islet cell lines and insulin secretion).
منابع مشابه
The Influence of Securigera securidaca on Diabetes Management in Animal Models: A Systematic Review
Background and Objective: It has been reported that allopathic drugs do not have significant effects on diabetes treatment. In contemporary literature, much attention has been given to the potential use of traditional medicines, including medicinal plants, in the treatment of metabolic abnormalities. Indeed, the effect of Securigera securidaca, as a medicinal agent, in alleviating the complicat...
متن کاملModeling of Self-Healing Concrete: A Review
Self-healing concrete (SHC) has received a tremendous attention due to its advanced ability of automatic crack detection and crack repairing compared to the standard concrete. Two main approaches which considered as to-date self-healing mechanisms are autogenous and autonomous healing. In the past several years, the effort of the research has been focused on experimental works instead of numeri...
متن کاملA review on West African Ebola epidemic dynamics models
Background and aims: The world is threatened by disease outbreak that reaches a public health emergency of international concern, studies to inform public and agencies for effective containment strategy are necessary. Several studies provided vital information of the dynamics and control of Ebola epidemic outbreak in West Africa. Methodologies and techniques in those researches...
متن کاملPharmacogenomics of glibenclamide in patients with type 2 diabetes mellitus: A systematic review
Introduction: One of the most widely used anti-diabetic drugs is sulfonylureas, which is often used as one of the first-line drugs in the treatment of type 2 diabetes. Due to the effect of the patient's genetic structure on the drug response (personalized medicine), the identification of genetic variations not only reduces the rate of adverse drug reactions but can also predict the effectivenes...
متن کاملAutism Treatment and Family Support Models Review
Autism is a lifelong neurological disability of unknown etiology. The criteria for a diagnosis of autism are based on a triad of impairments in social interaction, communication and a lack of flexibility in thinking and behavior There are several factors which are likely to contribute to this variation including the definition of autism and variability in diagnosis amongst professionals, howeve...
متن کامل